CBCB faculty Eytan Ruppin’s group publish a paper in Cell on predicting cancer-specific vulnerability

Wed Sep 03, 2014
CBCB faculty Eytan Ruppin's group has published a paper, led by Livnat Jerby, titled “Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality” on Aug. 1, 2014, in the journal Cell. This article describes their development of a computational pipeline that identifies synthetic lethal interactions by analyzing large cohorts of genetic and molecular data of clinical cancer samples. With their experimental collaborators from the Beatson (Gottlieb) and the Broad (Clemons) institutes, they show that synthetic lethality networks can be used to successfully predict the response of cancer cells to various drugs and other treatments, as well as to predict clinical prognosis.

“Predicting Cancer-Specific Vulnerability via Data-Driven Detection of Synthetic Lethality” article: http://ac.els-cdn.com/S0092867414009775/1-s2.0-S0092867414009775-main.pd...