Sridhar Hannenhalli

3104G Biomolecular Sciences Building
(301) 405-8219
Ph.D., Pennsylvania State University (Computer Science)

Dr. Hannenhalli is an associate professor in the department of Cell Biology and Molecular Genetics at the University of Maryland and also in the Center for Bioinformatics and Computational Biology. He also holds an affiliate position in Computer Science department at the University of Maryland and also in the department of Genetics at the University of Pennsylvania. He received his PhD in 1996 in Computer Science from The Pennsylvania State University where he developed combinatorial algorithms for genome rearrangement problems.

He has previously held research positions at Glaxo Smithkline, Celera Genomics and as Assistant and then Associate professor in the department of Genetics at the University of Pennsylvania. He has served on program committee for numerous bioinformatics conferences and chaired WABI and RECOMB conferences. He has also served on several national and international grant review panels and as academic editor for PLoS ONE and BMC genomics. He is co-authored over 75 papers in computer science and bioinformatics. His current research focus is on comparative genomics, transcriptional regulation and evolution.



Wang K, Cao K, Hannenhalli S.  2015.  Chromatin and genomic determinants of alternative splicing. BCB '15 Proceedings of the 6th ACM Conference on Bioinformatics, Computational Biology and Health Informatics .


Plasschaert R.N, Vigneau S., Tempera I., Gupta R., Maksimoska J., Everett L., Davuluri R., Mamorstein R., Lieberman P.M, Schultz D. et al..  2014.  CTCF binding site sequence differences are associated with unique regulatory and functional trends during embryonic stem cell differentiation. Nucleic Acids ResNucleic Acids ResNucleic Acids Res. 42:774-89.


Mukherjee R., Singh L.NS, Evans P., Hannenhalli S.  2013.  Correlated evolution of positions within mammalian cis elements . Plos One. 8:e55521.

Choi S.S, Hannenhalli S.  2013.  Three independent determinants of protein evolutionary rate. J Mol EvolJ Mol EvolJ Mol Evol. 76:98-111.

Mahmoudabadi G, Rajagopalan K, Getzenberg RH, Hannenhalli S, Rangarajan G, Kulkarni P.  2013.  Intrinsically disordered proteins and conformational noise: Implications in cancer. Cell CycleCell Cycle. 12

Malin J., Aniba M.R, Hannenhalli S.  2013.  Enhancer networks revealed by correlated DNAse hypersensitivity states of enhancers. Nucleic Acids ResNucleic Acids ResNucleic Acids Res. 41:6828-38.

Wang H, Duggal G, Patro R, Girvan M, Hannenhalli S, Kingsford C.  2013.  Topological properties of chromosome conformation graphs reflect spatial proximities within chromatin. Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics.

Wang K, Das A, Xiong Z-M, Cao K, Hannenhalli S.  2013.  Identification of gene clusters with phenotype-dependent expression with application to normal and premature ageing. Proceedings of the International Conference on Bioinformatics, Computational Biology and Biomedical Informatics.


Khaladkar M, Hannenhalli S.  2012.  Functional Divergence of Gene Duplicates a Domain-centric view. BMC Evolutionary BiologyBMC Evolutionary Biology.

Li J, Nina B, Lan C, Mary C, Hannenhalli S, Xiaohong Z, P. Thomas C, Parmacek MS.  2012.  Myocardin-like Protein (MKL)-2 Regulates TGF-beta Signaling. Embryonic Stem Cells and the Developing Vasculature DevelopmentEmbryonic Stem Cells and the Developing Vasculature Development.

D. Avinash S, Aniba R., Chang Y.C, Hannenhalli S.  2012.  Epigenomic model of cardiac enhancers with application to Genome wideassociation studies. Pacific Symposium on BiocomputingPacific Symposium on Biocomputing.

G. Christopher V, Lucia P, Jennifer H.KChoi, Mathieu W, Devan J, J. Pepe H, Jennifer B, Karuna M, J. Alan P, Hannenhalli S et al..  2012.  Genomic analysis of sleep deprivation reveals translational regulation in the hippocampus. Physiological GenomicsPhysiological Genomics.


Tian Y, Zhang Y, Hurd L, Hannenhalli S, Liu F, Lu MMin, Morrisey EE.  2011.  Regulation of Lung Endoderm Progenitor Cell Behavior by miR302/367. DevelopmentDevelopmentDevelopmentDevelopment. 138

Yaklichkin SYu, Darnell DK, Pier MV, Antin PB, Hannenhalli S.  2011.  Accelerated evolution of 3'avian FOXE1 genes, and thyroid and feather specific expression of chicken FoxE1. BMC Evolutionary BiologyBMC Evolutionary Biology. 11

Dewey F.E, Perez M.V, Wheeler M.T, Watt C., Spin J., Langfelder P., Horvath S., Hannenhalli S, Cappola T.P, Ashley E.A.  2011.  Gene Coexpression Network Topology of Cardiac Development, Hypertrophy, and FailureClinical Perspective. Circulation: cardiovascular geneticsCirculation: Cardiovascular Genetics. 4

Khaladkar M., Smyda M., Hannenhalli S.  2011.  Epigenomic and RNA structural correlates of polyadenylation. RNA biologyRNA biology. 8

Everett LJ, Jensen ST, Hannenhalli S.  2011.  Transcriptional Regulation Via TF-Modifying Enzymes: An Integrative Model-Based Analysis. Nucleic Acids ResearchNucl. Acids Res.Nucleic Acids ResearchNucl. Acids Res.. 39

Vishnoi A, Sethupathy P, Simola D, Plotkin JB, Hannenhalli S.  2011.  Genome-Wide Survey of Natural Selection on Functional, Structural, and Network Properties of Polymorphic Sites in Saccharomyces Paradoxus. Molecular Biology and EvolutionMol Biol EvolMolecular Biology and EvolutionMol Biol Evol. 28


Singh LN, Hannenhalli S.  2010.  Correlated Changes Between Regulatory Cis Elements and Condition-Specific Expression in Paralogous Gene Families. Nucleic Acids ResearchNucl. Acids Res.Nucleic Acids ResearchNucl. Acids Res.. 38

Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJin, Li L, Hannenhalli S, Epstein JA.  2010.  Hopx and Hdac2 Interact to Modulate Gata4 Acetylation and Embryonic Cardiac Myocyte Proliferation. Developmental CellDevelopmental Cell. 19

Vishnoi A, Kryazhimskiy S, Bazykin GA, Hannenhalli S, Plotkin JB.  2010.  Young Proteins Experience More Variable Selection Pressures Than Old Proteins. Genome ResearchGenome Res.Genome ResearchGenome Res.. 20

Hansen M, Everett L, Singh L, Hannenhalli S.  2010.  Mimosa: Mixture model of co-expression to detect modulators of regulatory interaction. Algorithms for Molecular BiologyAlgorithms for Molecular Biology. 5

Everett L., Hansen M., Hannenhalli S.  2010.  Regulating the regulators: modulators of transcription factor activity. Methods Mol. BiolMethods Mol. Biol. 674


Qasim AN, Metkus TS, Tadesse M, Lehrke M, Restine S, Wolfe ML, Hannenhalli S, Cappola T, Rader DJ, Reilly MP.  2009.  Resistin gene variation is associated with systemic inflammation but not plasma adipokine levels, metabolic syndrome or coronary atherosclerosis in nondiabetic Caucasians. Clinical EndocrinologyClinical Endocrinology. 70

Essien K, Vigneau S, Apreleva S, Singh LN, Bartolomei MS, Hannenhalli S.  2009.  CTCF binding site classes exhibit distinct evolutionary, genomic, epigenomic and transcriptomic features. Genome BiologyGenome Biology. 10

Shah R, Lu Y, Hinkle CC, McGillicuddy FC, Kim R, Hannenhalli S, Cappola TP, Heffron S, Wang XM, Mehta NN et al..  2009.  Gene Profiling of Human Adipose Tissue During Evoked Inflammation In Vivo. DiabetesDiabetesDiabetesDiabetes. 58

Putt M.E, Hannenhalli S, Lu Y., Haines P., Chandrupatla H.R, Morrisey E.E, Margulies K.B, Cappola T.P.  2009.  Evidence for Coregulation of Myocardial Gene Expression by MEF2 and NFAT in Human Heart FailureCLINICAL PERSPECTIVE. Circulation: Cardiovascular GeneticsCirculation: Cardiovascular Genetics. 2

Hannenhalli S, Kaestner KH.  2009.  The evolution of Fox genes and their role in development and disease. Nature reviews. GeneticsNat Rev GenetNature reviews. GeneticsNat Rev Genet. 10

Hansen M., Everett L., Singh L., Hannenhalli S.  2009.  Mimosa: mixture model of co-expression to detect modulators of regulatory interaction. Algorithms in BioinformaticsAlgorithms in Bioinformatics.


Giancarlo R., Hannenhalli S.  2008.  Guest Editors' Introduction to the Special Section on Algorithms in Bioinformatics (WABI'07). IEEE/ACM Transactions on Computational Biology and BioinformaticsIEEE/ACM Transactions on Computational Biology and Bioinformatics.

Sethupathy P, Hannenhalli S.  2008.  A Tutorial of the Poisson Random Field Model in Population Genetics. Advances in BioinformaticsAdvances in Bioinformatics. 2008

Fermin D.R, Barac A., Lee S., Polster S.P, Hannenhalli S, Bergemann T.L, Grindle S., Dyke D.B, Pagani F., Miller L.W et al..  2008.  Sex and age dimorphism of myocardial gene expression in nonischemic human heart failure. Circulation: Cardiovascular GeneticsCirculation: Cardiovascular Genetics. 1

Hannenhalli S.  2008.  BIOINFORMATICS REVIEW. BIOINFORMATICSBioinformatics. 24

Sethupathy P, Giang H, Plotkin JB, Hannenhalli S.  2008.  Genome-Wide Analysis of Natural Selection on Human Cis-Elements. PLoS ONEPLoS ONEPLoS ONEPLoS ONE. 3

Wan L.B, Pan H., Hannenhalli S, Cheng Y., Ma J., Fedoriw A., Lobanenkov V., Latham K.E, Schultz R.M, Bartolomei M.S.  2008.  Maternal depletion of CTCF reveals multiple functions during oocyte and preimplantation embryo development. DevelopmentDevelopment. 135


Singh L.N, Wang L.S, Hannenhalli S.  2007.  TREMOR—a tool for retrieving transcriptional modules by incorporating motif covariance. Nucleic acids researchNucleic Acids Research. 35

Minkah N, Hwang Y, Perry K, Van Duyne GD, Hendrickson R, Lefkowitz EJ, Hannenhalli S, Bushman FD.  2007.  Variola virus topoisomerase: DNA cleavage specificity and distribution of sites in Poxvirus genomes. VirologyVirology. 365

Zhang Y, Rath N, Hannenhalli S, Wang Z, Cappola T, Kimura S, Atochina-Vasserman E, Lu MMin, Beers MF, Morrisey EE.  2007.  GATA and Nkx factors synergistically regulate tissue-specific gene expression and development in vivo. DevelopmentDevelopment. 134

Hannenhalli S.  2007.  Eukaryotic Transcriptional Regulation: Signals, Interactions, and Modules. Computational Genomics: Current MethodsComputational Genomics: Current Methods.

Leparc G.G, Mitra R.D, Vardhanabhuti S., Wang J., Hannenhalli S, Smit S., Widmann J., Knight R., Wu S., Zhang Y. et al..  2007.  COMPUTATIONAL BIOLOGY. Nucleic acids researchNucleic Acids Research. 35


Ross DA, Hannenhalli S, Tobias JW, Cooch N, Shiekhattar R, Kadesch T.  2006.  Functional Analysis of Hes-1 in Preadipocytes. Molecular EndocrinologyMolecular EndocrinologyMolecular EndocrinologyMolecular Endocrinology. 20

Lewinski M.K, Yamashita M., Emerman M., Ciuffi A., Marshall H., Crawford G., Collins F., Shinn P., Leipzig J., Hannenhalli S et al..  2006.  Retroviral DNA integration: viral and cellular determinants of target-site selection. PLoS pathogensPLoS pathogens. 2

Everett L, San Wang L-, Hannenhalli S.  2006.  Dense Subgraph Computation Via Stochastic Search: Application to Detect Transcriptional Modules. BioinformaticsBioinformaticsBioinformaticsBioinformatics. 22

Hannenhalli S, Middleton R.P, Levy S., Perroud B., Holzwarth J.A, McDonald K., Hannah S.S,.  2006.  Identification and cross-species comparison of canine osteoarthritic gene regulatory cis-elements. Osteoarthritis and cartilage/OARS, Osteoarthritis Research SocietyOsteoarthritis and cartilage/OARS, Osteoarthritis Research Society. 14

Keeley MB, Wood MA, Isiegas C, Stein J, Hellman K, Hannenhalli S, Abel T.  2006.  Differential Transcriptional Response to Nonassociative and Associative Components of Classical Fear Conditioning in the Amygdala and Hippocampus. Learning & MemoryLearn. Mem.Learning & MemoryLearn. Mem.. 13

Hadley D., Murphy T., Valladares O., Hannenhalli S, Ungar L., Kim J., Bucan M.,.  2006.  Patterns of sequence conservation in presynaptic neural genes. Genome BiolGenome Biol. 7

Berry C, Hannenhalli S, Leipzig J, Bushman FD.  2006.  Selection of Target Sites for Mobile DNA Integration in the Human Genome. PLoS Comput BiolPLoS Comput BiolPLoS Comput BiolPLoS Comput Biol. 2

Wang L.S, Jensen S., Hannenhalli S.  2006.  An interaction-dependent model for transcription factor binding. Systems Biology and Regulatory GenomicsSystems Biology and Regulatory Genomics.

Hannenhalli S.  2006.  Invited Talk: Deciphering Gene Regulatory Networks by in silico approaches. 6th International Workshop on Data Mining in Bioinformatics (BIOKDD06)6th International Workshop on Data Mining in Bioinformatics (BIOKDD06).

Hannenhalli S, Putt ME, Gilmore JM, Wang J, Parmacek MS, Epstein JA, Morrisey EE, Margulies KB, Cappola TP.  2006.  Transcriptional Genomics Associates FOX Transcription Factors With Human Heart Failure. CirculationCirculation. 114

Wang J, Hannenhalli S.  2006.  A mammalian promoter model links cis elements to genetic networks. Biochemical and Biophysical Research CommunicationsBiochemical and Biophysical Research Communications. 347

Hinsch H, Hannenhalli S.  2006.  Recurring genomic breaks in independent lineages support genomic fragility. BMC Evolutionary BiologyBMC Evolutionary Biology. 6

Evans P, Donahue G, Hannenhalli S.  2006.  Conservation Patterns in cis-Elements Reveal Compensatory Mutations. Comparative GenomicsComparative Genomics. 4205


Hannenhalli S, Wang L.S.  2005.  Enhanced position weight matrices using mixture models. BioinformaticsBioinformatics. 21

Simola D.F, Dalva M., Hannenhalli S, Liebhaber S., Bucan M., Ungar L..  2005.  Post-transcriptional Control in Mammalian Dendrites.