| Citation |
Ben Langmead, Cole Trapnell, Mihai Pop, Steven L. Salzberg
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome
Genome Biology, 10:R25 (2009) |
| Abstract |
Bowtie is an ultrafast, memory-efficient alignment program for aligning short DNA sequence reads to large genomes. For the human genome, Burrows-Wheeler indexing allows Bowtie to align more than 25 million reads per CPU hour with a memory footprint of approximately 1.3 gigabytes. Bowtie extends previous Burrows-Wheeler techniques with a novel quality-aware backtracking algorithm that permits mismatches. Multiple processor cores can be used simultaneously to achieve even greater alignment speeds. Bowtie is open source and available at http://bowtie.cbcb.umd.edu. |
| doi |
doi:10.1186/gb-2009-10-3-r25
|
| URL |
http://genomebiology.com/2009/10/3/R25
|
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