@article {38460,
	title = {Regulation of Lung Endoderm Progenitor Cell Behavior by miR302/367},
	journal = {DevelopmentDevelopmentDevelopmentDevelopment},
	volume = {138},
	year = {2011},
	type = {10.1242/dev.061762},
	abstract = {The temporal and spatial control of organ-specific endoderm progenitor development is poorly understood. miRNAs affect cell function by regulating programmatic changes in protein expression levels. We show that the miR302/367 cluster is a target of the transcription factor Gata6 in mouse lung endoderm and regulates multiple aspects of early lung endoderm progenitor development. miR302/367 is expressed at early stages of lung development, but its levels decline rapidly as development proceeds. Gain- and loss-of-function studies show that altering miR302/367 expression disrupts the balance of lung endoderm progenitor proliferation and differentiation, as well as apical-basal polarity. Increased miR302/367 expression results in the formation of an undifferentiated multi-layered lung endoderm, whereas loss of miR302/367 activity results in decreased proliferation and enhanced lung endoderm differentiation. miR302/367 coordinates the balance between proliferation and differentiation, in part, through direct regulation of Rbl2 and Cdkn1a, whereas apical-basal polarity is controlled by regulation of Tiam1 and Lis1. Thus, miR302/367 directs lung endoderm development by coordinating multiple aspects of progenitor cell behavior, including proliferation, differentiation and apical-basal polarity.},
	keywords = {Lung, MicroRNA, mouse, Progenitor},
	isbn = {0950-1991, 1477-9129},
	author = {Tian, Ying and Zhang, Yuzhen and Hurd, Laura and Sridhar Hannenhalli and Liu, Feiyan and Lu, Min Min and Morrisey, Edward E.}
}
